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1

Crystal structure of carboxypeptidase G2, a bacterial enzyme with applications in cancer therapy

Siân Rowsell, Richard A Pauptit, Alec D Tucker, Roger G Melton, David M Blow, Peter Brick

Journal:

Year:

1997

Language:

english

File:

PDF, 981 KB

english, 1997

2

Imidazo[1,2-b]pyridazines: a potent and selective class of cyclin-dependent kinase inhibitors

Kate F Byth, Nicola Cooper, Janet D Culshaw, David W Heaton, Sandra E Oakes, Claire A Minshull, Richard A Norman, Richard A Pauptit, Julie A Tucker, Jason Breed, Andrew Pannifer, Siân Rowsell, Judith

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 342 KB

english, 2004

3

Structure of IL-17A in Complex with a Potent, Fully Human Neutralizing Antibody

Stefan Gerhardt, W. Mark Abbott, David Hargreaves, Richard A. Pauptit, Rick A. Davies, Maurice R.C. Needham, Caroline Langham, Wendy Barker, Azad Aziz, Melanie J. Snow, Sarah Dawson, Fraser Welsh, Tre

Journal:

Journal of Molecular Biology

Year:

2009

Language:

english

File:

PDF, 1.57 MB

english, 2009

4

Engineering a High-Affinity Anti-IL-15 Antibody: Crystal Structure Reveals an α-Helix in VH CDR3 as Key Component of Paratope

David C. Lowe, Stefan Gerhardt, Alison Ward, David Hargreaves, Malcolm Anderson, Franco Ferraro, Richard A. Pauptit, Debbie V. Pattison, Catriona Buchanan, Bojana Popovic, Donna K. Finch, Trevor Wilki

Journal:

Journal of Molecular Biology

Year:

2011

Language:

english

File:

PDF, 2.13 MB

english, 2011

5

The high-resolution crystal structure of a 24-kDa gyrase B fragment from E. coli complexed with one of the most potent coumarin inhibitors, clorobiocin

Francis T.F. Tsai, Onkar M.P. Singh, Tadeusz Skarzynski, Alan J. Wonacott, Simon Weston, Alec Tucker, Richard A. Pauptit, Alexander L. Breeze, J. Philip Poyser, Ronan O'Brien, John E. Ladbury, Dale B.

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

1997

Language:

english

File:

PDF, 347 KB

english, 1997

6

Cyclin-dependent kinase 4 inhibitors as a treatment for cancer. Part 1: identification and optimisation of substituted 4,6-Bis anilino pyrimidines

John F. Beattie, Gloria A. Breault, Rebecca P.A. Ellston, Stephen Green, Philip J. Jewsbury, Catherine J. Midgley, Russell T. Naven, Claire A. Minshull, Richard A. Pauptit, Julie A. Tucker, J.Elizabet

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 332 KB

english, 2003

7

Imidazo[1,2-a]pyridines: A potent and selective class of cyclin-Dependent kinase inhibitors identified through structure-Based hybridisation

Malcolm Anderson, John F. Beattie, Gloria A. Breault, Jason Breed, Kate F. Byth, Janet D. Culshaw, Rebecca P.A. Ellston, Stephen Green, Claire A. Minshull, Richard A. Norman, Richard A. Pauptit, Judit

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 333 KB

english, 2003

8

Cyclin-dependent kinase 4 inhibitors as a treatment for cancer. Part 2: identification and optimisation of substituted 2,4-bis anilino pyrimidines

Gloria A. Breault, Rebecca P.A. Ellston, Stephen Green, S.Russell James, Philip J. Jewsbury, Catherine J. Midgley, Richard A. Pauptit, Claire A. Minshull, Julie A. Tucker, J.Elizabeth Pease

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 350 KB

english, 2003

9

Binding of the potential antitumour agent indirubin-5-sulphonate at the inhibitor site of rabbit muscle glycogen phosphorylase b : Comparison with ligand binding to pCDK2–cyclin A complex

Magda N. Kosmopoulou, Demetres D. Leonidas, Evangelia D. Chrysina, Nicolas Bischler, Gerhard Eisenbrand, Constantinos E. Sakarellos, Richard Pauptit, Nikos G. Oikonomakos

Journal:

Year:

2004

Language:

english

File:

PDF, 669 KB

english, 2004

10

Crystal structure of a Src-homology 3 (SH3) domain

Musacchio, Andrea, Noble, Martin, Pauptit, Richard, Wierenga, Rik, Saraste, Matti

Journal:

Year:

1992

File:

PDF, 700 KB

1992

11

The discovery of N-cyclopropyl-4-methyl-3-[6-(4-methylpiperazin-1-yl)-4-oxoquinazolin-3(4H)-yl]benzamide (AZD6703), a clinical p38α MAP kinase inhibitor for the treatment of inflammatory diseases

Dearg S. Brown, John G. Cumming, Paul Bethel, Jonathan Finlayson, Stefan Gerhardt, Ian Nash, Richard A. Pauptit, Kurt G. Pike, Alan Reid, Wendy Snelson, Steve Swallow, Caroline Thompson

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 864 KB

english, 2012

12

The structure of neutral protease from Bacillus cereus at 0.2-nm resolution

Wilhelm STARK, Richard A. PAUPTIT, Keith S. WILSON, Johan N. JANSONIUS

Journal:

Year:

1992

Language:

english

File:

PDF, 1.07 MB

english, 1992

13

Crystallization and Preliminary X-ray Analysis of the Periplasmic Fragment of CyoA-a Subunit of the Escherichia coli Cytochrome o Complex

John van der Oost, Andrea Musacchio, Richard A. Pauptit, Thomas A. Ceska, Rik K. Wierenga, Matti Saraste

Journal:

Journal of Molecular Biology

Year:

1993

File:

PDF, 203 KB

1993

14

X-ray Structure of Recombinant Ricin A-Chain at 1.8 Å Resolution

Simon A. Weston, Alec D. Tucker, David R. Thatcher, Dean J. Derbyshire, Richard A. Pauptit

Journal:

Journal of Molecular Biology

Year:

1994

File:

PDF, 890 KB

1994

15

Structural studies on improved crystals of the photosystem I reaction centre from Phormidium laminosum

Robert C. Ford, Richard A. Pauptit, Andreas Holzenburg

Journal:

Year:

1988

Language:

english

File:

PDF, 932 KB

english, 1988

16

Crystallization and preliminary X-ray diffraction studies of dialkylglycine decarboxylase, a decarboxylating transaminase

Michael D. Toney, John W. Keller, Richard A. Pauptit, Joachim Jaeger, Matthew K. Wise, Ursula Sauder, Johan N. Jansonius

Journal:

Journal of Molecular Biology

Year:

1991

Language:

english

File:

PDF, 297 KB

english, 1991

17

Crystal Structures of Human ADAMTS-1 Reveal a Conserved Catalytic Domain and a Disintegrin-like Domain with a Fold Homologous to Cysteine-Rich Domains

Stefan Gerhardt, Giles Hassall, Paul Hawtin, Eileen McCall, Liz Flavell, Claire Minshull, David Hargreaves, Attilla Ting, Richard A. Pauptit, Andrew E. Parker, W. Mark Abbott

Journal:

Journal of Molecular Biology

Year:

2007

Language:

english

File:

PDF, 1.63 MB

english, 2007

18

Crystal Structure of Human MMP9 in Complex with a Reverse Hydroxamate Inhibitor

Siân Rowsell, Paul Hawtin, Claire A. Minshull, Holly Jepson, Sarah M.V. Brockbank, Derek G. Barratt, Anthony M. Slater, William L. McPheat, David Waterson, Adriano M. Henney, Richard A. Pauptit

Journal:

Journal of Molecular Biology

Year:

2002

Language:

english

File:

PDF, 508 KB

english, 2002

19

Crystallization and preliminary X-ray characterization of maltoporin from Escherichia coli

Kathrin A. Stauffer, Malcolm G.P. Page, Ariane Hardmeyer, Thomas A. Keller, Richard A. Pauptit

Journal:

Journal of Molecular Biology

Year:

1990

Language:

english

File:

PDF, 306 KB

english, 1990

20

Crystallization and preliminary X-Ray diffraction studies of the N-terminal domain of the phosphorylating subunit of mannose permease from Escherichia coli

Jean-Claude Génovésio-Taverne, Ursula Sauder, Richard A. Pauptit, Johan N. Jansonius, Bernhard Erni

Journal:

Journal of Molecular Biology

Year:

1990

Language:

english

File:

PDF, 267 KB

english, 1990

21

Trigonal crystals of porin from Escherichia coli

Richard A. Pauptit, Hong Zhang, Gabriele Rummel, Schirmer Tilman, Johan N. Jansonius, Jürg P. Rosenbusch

Journal:

Journal of Molecular Biology

Year:

1991

Language:

english

File:

PDF, 383 KB

english, 1991

22

A common channel-forming motif in evolutionarily distant porins

Richard A. Pauptit, Tilman Schirmer, Johan N. Jansonius, Arg P. Rosenbusch, Michael W. Parker, Alec D. Tucker, Demetrius Tsernoglou, Manfred S. Weiss, Georg E. Schulzt

Journal:

Journal of Structural Biology

Year:

1991

Language:

english

File:

PDF, 10.69 MB

english, 1991

23

Trigonal crystals of porcine mitochondrial aspartate aminotransferase

Tina Izard, Bruno Fol, Richard A. Pauptit, Johan N. Jansonius

Journal:

Journal of Molecular Biology

Year:

1990

Language:

english

File:

PDF, 324 KB

english, 1990

24

The Entropic Penalty of Ordered Water Accounts for Weaker Binding of the Antibiotic Novobiocin to a Resistant Mutant of DNA Gyrase: A Thermodynamic and Crystallographic Study ‡

Holdgate, Geoffrey A., Tunnicliffe, Alan, Ward, Walter H. J., Weston, Simon A., Rosenbrock, Gina, Barth, Peter T., Taylor, Ian W. F., Pauptit, Richard A., Timms, David

Journal:

Year:

1997

Language:

english

File:

PDF, 488 KB

english, 1997

25

Kinetic and Structural Characteristics of the Inhibition of Enoyl (Acyl Carrier Protein) Reductase by Triclosan ‡

Ward, Walter H. J., Holdgate, Geoffrey A., Rowsell, Siân, McLean, Estelle G., Pauptit, Richard A., Clayton, Edward, Nichols, Wright W., Colls, Jeremy G., Minshull, Claire A., Jude, David A., Mistry, A

Journal:

Year:

1999

Language:

english

File:

PDF, 229 KB

english, 1999

26

Crystal structure of neutral protease from Bacillus cereus refined at 3.0A˚resolution and comparison with the homologous but more thermostable enzyme thermolysin

Pauptit, Richard A., Karlsson, Rolf, Picot, Daniel, Jenkins, John A., Niklaus-Reimer, Ann-Sofie, Jansonius, Johan N.

Journal:

Journal of Molecular Biology

Year:

1988

Language:

english

File:

PDF, 1.61 MB

english, 1988

27

Prevention of MKK6-Dependent Activation by Binding to p38α MAP Kinase ‡

Sullivan, Jane E., Holdgate, Geoffrey A., Campbell, Douglas, Timms, David, Gerhardt, Stefan, Breed, Jason, Breeze, Alexander L., Bermingham, Alun, Pauptit, Richard A., Norman, Richard A., Embrey, Kevi

Journal:

Year:

2005

Language:

english

File:

PDF, 613 KB

english, 2005

28

Crystal structures of an α-cyclobutyl tricyclic enone and its p -bromobenzoate derivative

Pauptit, Richard A., Trotter, James

Journal:

Canadian Journal of Chemistry

Year:

1983

Language:

english

File:

PDF, 365 KB

english, 1983

29

Crystal structure of a stemodin intermediate

Pauptit, Richard A., Trotter, James

Journal:

Canadian Journal of Chemistry

Year:

1981

Language:

english

File:

PDF, 152 KB

english, 1981

30

Crystal structures of racemic and optically active 4,4′-dimethyl-1,1′-binaphthyl

Pauptit, Richard A., Trotter, James

Journal:

Canadian Journal of Chemistry

Year:

1981

Language:

english

File:

PDF, 202 KB

english, 1981

31

Crystal structure of camphor-1,4-homoenol p -bromobenzoate

Pauptit, Richard A., Trotter, James

Journal:

Canadian Journal of Chemistry

Year:

1980

Language:

english

File:

PDF, 151 KB

english, 1980

32

Crystal structure of raucubaine

Pauptit, Richard A., Trotter, James

Journal:

Canadian Journal of Chemistry

Year:

1981

Language:

english

File:

PDF, 152 KB

english, 1981

33

Crystal structures of optically active naphthidine (4,4′-diamino-1,1′-binaphthyl) and 1,1′-binaphthyl

Pauptit, Richard A., Trotter, James

Journal:

Canadian Journal of Chemistry

Year:

1983

Language:

english

File:

PDF, 207 KB

english, 1983

34

Three-dimensional structure of a mutant E.coli aspartate aminotransferase with increased enzymic activity

Jäger, Joachim, Pauptit, Richard A., Sauder, Ursula, Jansonius, Johan N.

Journal:

Protein Engineering Design and Selection

Year:

1994

Language:

english

File:

PDF, 2.42 MB

english, 1994

35

Study of the interaction of the medium chain μ2 subunit of the clathrin-associated adapter protein complex 2 with cytotoxic T-lymphocyte antigen 4 and CD28

FOLLOWS, Emily R., McPHEAT, Jane C., MINSHULL, Claire, MOORE, Nel C., PAUPTIT, Richard A., ROWSELL, Siân, STACEY, Claire L., STANWAY, Judith J., TAYLOR, Ian W.F., ABBOTT, W. Mark

Journal:

Biochemical Journal

Year:

2001

Language:

english

File:

PDF, 259 KB

english, 2001

36

A structural comparison of the colicin immunity proteins Im7 and Im9 gives new insights into the molecular determinants of immunity-protein specificity

DENNIS, Caitríona A., VIDELER, Hortense, PAUPTIT, Richard A., WALLIS, Russell, JAMES, Richard, MOORE, Geoffrey R., KLEANTHOUS, Colin

Journal:

Biochemical Journal

Year:

1998

Language:

english

File:

PDF, 576 KB

english, 1998

37

Study of the interaction of the medium chain μ2 subunit of the clathrin-associated adapter protein complex 2 with cytotoxic T-lymphocyte antigen 4 and CD28

FOLLOWS, Emily R., McPHEAT, Jane C., MINSHULL, Claire, MOORE, Nel C., PAUPTIT, Richard A., ROWSELL, Siân, STACEY, Claire L., STANWAY, Judith J., TAYLOR, Ian W. F., ABBOTT, W. Mark

Journal:

Biochemical Journal

Year:

2001

Language:

english

File:

PDF, 259 KB

english, 2001

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